Clinical trial to validate Sudbury-developed cancer test

An international clinical trial to validate the use of the RNA Disruption Assay (RDA) tool for treatment and management of breast cancer has been launched in North America and Europe.

The RNA Disruption Assay test was developed by Health Sciences North Research Institute scientist and Laurentian University professor Dr. Amadeo Parissenti and research associate Dr. Baoqing Guo.

The clinical trial, code-named BREVITY, will include 500+ patients with invasive breast cancer, scheduled to receive neoadjuvant chemotherapy, in 40 centers across Europe and North America, including Sudbury’s Northeast Cancer Centre.

The test measures tumor response 14 days after the first cycle of treatment. It is expected to become a critical tool for managing response-guided therapy.

“I am delighted that so many highly regarded clinical research groups worldwide are participating in the BREVITY trial,” said Parissenti. “This speaks highly of the strong potential that RDA has to better manage the care of cancer patients through its ability to monitor response and predict survival after neoadjuvant chemotherapy.

“Using RDA to identify patients with chemo-resistant tumors early in treatment could help reduce the toxic side effects from ineffective chemotherapy drugs, while permitting patients to move rapidly to alternate treatments, such as surgery, radiation therapy, or other drugs.”

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